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Human HVEM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Human HVEM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

HVEM Recombinant Protein

CATALOG NUMBER: 96-886

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Leu 39 - Val 202
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Predicted Molecular Weight:
19.2 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human HVEM, His Tag at 0.5 ug/mL (100 uL/well) can bind Human BTLA, Fc Tag with a linear range of 0.078-2.5 ug/mL.
Purity:
>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
HVEM
Additional Names:
TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270
Protein Accession Number:
NP_003811
Ncbi Gene Id Number:
8764
Background:
Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFbeta (lymphotoxin alpha) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTbetaR, the receptor for lymphotoxin alphabeta heterotrimer. The role of the HVEM LIGHT /LTbeta receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
Background Reference 1:
Hsu, H. et al., 1997, J. Biol. Chem. 272:13471.
Background Reference 2:
Mauri, D.N. et al., 1998, Immunity 8:21.
Background Reference 3:
Montgomery, R.I. et al., 1996, Cell 87:427.
Background Reference 4:
Cheung,T.C.et al., 2005, Proc.Natl.Acad.Sci.USA102:13218-23.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-886

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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