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Western blot analysis of HYAL2 Antibody Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate.
HYAL2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis of HYAL2 Antibody Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate.

HYAL2 Antibody

CATALOG NUMBER: 56-460

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human HYAL2.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
54 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
HYAL2
Additional Names:
Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
Protein Accession Number:
Q12891
Protein Gi Number:
311033483
Ncbi Gene Id Number:
8692
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a weak acid-active hyaluronidase. Theencoded protein is similar in structure to other more activehyaluronidases. Hyaluronidases degrade hyaluronan, one of the majorglycosaminoglycans of the extracellular matrix. Hyaluronan andfragments of hyaluronan are thought to be involved in cellproliferation, migration and differentiation. Although it waspreviously thought to be a lysosomal hyaluronidase that is activeat a pH below 4, the encoded protein is likely a GPI-anchored cellsurface protein. This hyaluronidase serves as a receptor for theoncogenic virus Jaagsiekte sheep retrovirus. The gene is one ofseveral related genes in a region of chromosome 3p21.3 associatedwith tumor suppression. This gene encodes two alternatively splicedtranscript variants which differ only in the 5' UTR.
Background Reference 1:
Monzon, M.E., et al. J. Biol. Chem. 285(34):26126-26134(2010)
Background Reference 2:
Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
Background Reference 3:
de la Motte, C., et al. Am. J. Pathol. 174(6):2254-2264(2009)
Background Reference 4:
Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-460

List Size:
400 ul

List Price:

$495.00

Datasheet
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