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Western blot analysis of IA-6 in rat thymus tissue lysate with IA-6 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of IA-6 in rat thymus tissue lysate with IA-6 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

IA-6 Antibody

CATALOG NUMBER: 5417

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
IA-6 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human IA-6.
The immunogen is located within amino acids 340 - 390 of IA-6.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
IA-6 antibody can be used for detection of IA-6 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1471 - Rat Thymus Tissue Lysate
Purification:
IA-6 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
IA-6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
IA-6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
INSM2
Additional Names:
IA-6 Antibody: IA6, IA-6, mlt1, IA6, Nbla106, Insulinoma-associated protein 2, Zinc finger protein IA-6
Protein Accession Number:
AAI30380
Protein Gi Number:
120659844
Ncbi Gene Id Number:
84684
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
IA-6 Antibody: IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription.
Background Reference 1:
Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet.2004; 36:40-5.
Background Reference 2:
Wildner H, Gierl MS, Strehle M, et al. Insm (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympathoadrenal lineage. Dev.2008; 135:473-81.
Background Reference 3:
Trembleau S, Penna G, Grigori S, et al. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes. J. Immunol.2000; 165:6748-55.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5417

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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