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IGF1R (phospho Tyr1346) Antibody

CATALOG NUMBER: 79-831

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
IGF1R (phospho Tyr1346) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1346 (Q-P-Y (p)-A-H) derived from Human IGF1R .
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.
Predicted Molecular Weight:
154 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
IGF1R
Additional Names:
CD221, kinase IGF1R, IGF1R
Protein Accession Number:
NP_000866.1
Protein Gi Number:
4557665
Ncbi Gene Id Number:
3480
Background:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
Background Reference 1:
Ullrich A., EMBO J. 5:2503-2512(1986).
Background Reference 2:
Abbot A.M., J. Biol. Chem. 267:10759-10763(1992).
Background Reference 3:
The MGC Project Team;Genome Res. 14:2121-2127(2004).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-831

List Size:
0.1 mg

List Price:

$376.00

Datasheet
Shipping Info

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