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Western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the detected IKZF3 protein (arrow).
Western blot analysis of extracts from MM cells, treated with DMSO or lenalidomide, using rabbit polyclonal IKZF3 Antibody .
Western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the detected IKZF3 protein (arrow).

IKZF3 Antibody

CATALOG NUMBER: 61-999

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
58 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
IKZF3
Additional Names:
Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3
Protein Accession Number:
Q9UKT9
Protein Gi Number:
212276437
Ncbi Gene Id Number:
22806
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the Ikaros family ofzinc-finger proteins. Three members of this protein family (Ikaros,Aiolos and Helios) are hematopoietic-specific transcription factorsinvolved in the regulation of lymphocyte development. This geneproduct is a transcription factor that is important in theregulation of B lymphocyte proliferation and differentiation. BothIkaros and Aiolos can participate in chromatin remodeling.Regulation of gene expression in B lymphocytes by Aiolos is complexas it appears to require the sequential formation of Ikaroshomodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Atleast six alternative transcripts encoding different isoforms havebeen described.
Background Reference 1:
Billot, K., et al. Leuk. Res. 34(3):289-293(2010)
Background Reference 2:
Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)
Background Reference 3:
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
Background Reference 4:
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

61-999

List Size:
400 ul

List Price:

$495.00

Datasheet
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