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Human IL-12 R beta 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human IL-12 R beta 1, His Tag at 2 ug/mL (100 uL/well) can bind Human IL-12B, Fc Tag with a linear range of 0.078-1.25 ug/mL (QC tested).
Human IL-12 R beta 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

IL-12 R beta 1 / CD212 Recombinant Protein

CATALOG NUMBER: 11-385

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Cys 24 - Glu 540
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.0 kDa. The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
59.0 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
IL12RB1
Additional Names:
IL-12 R beta 1,IL12RB1,CD212,IL12R,IL12RB,IL-12RB1
Protein Accession Number:
NP_005526.1
Ncbi Gene Id Number:
3594
Background:
The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Background Reference 1:
Presky DH, et al. 1996. Proc Natl Acad Sci U S A. 93(24):14002-7.
Background Reference 2:
Parham C, rt al. 2002. J Immunol. 168(11):5699-708.
Background Reference 3:
Reeme AE, et al. 2018. Genes Immun. doi: 10.1038/s41435-018-0023-2.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-385

List Size:
0.1 mg

List Price:

$495.00

Datasheet
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