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Western blot analysis of IL-21 receptor expression in human Raji cell lysate with IL-21 receptor antibody at 1 μg/ml.
Immunofluorescence of IL-21 Receptor in A431 cells with IL-21 Receptor antibody at 20 μg/ml.<br><br>Green: IL-21 Receptor Antibody (2471) <br> Blue: DAPI staining
Western blot analysis of IL-21 receptor expression in human Raji cell lysate with IL-21 receptor antibody at 1 μg/ml.
Green Product
Trial Size

IL-21 Receptor Antibody

CATALOG NUMBER: 2471

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 20 to 32 of human IL-21 receptor precursor.
The immunogen is located within the first 50 amino acids of IL-21 Receptor.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 1 μg/mL. An approximately 60 kDa band can be detected. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1207 - Raji Cell Lysate
Predicted Molecular Weight:
60 kDa
Purification:
IL-21 Receptor Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
IL-21 Receptor Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/ml
Storage Conditions:
IL-21 Receptor antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
IL21R
Additional Names:
IL-21 Receptor Antibody: NILR, CD360, NILR, UNQ3121/PRO10273, Interleukin-21 receptor, Novel interleukin receptor, IL-21 receptor
Protein Accession Number:
NP_068570
Protein Gi Number:
11141869
Ncbi Gene Id Number:
50615
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
IL-21 Receptor Antibody: A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Background Reference 1:
Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408(6808):57-63.
Background Reference 2:
Ozaki K, Kikly K, Michalovich D, et al.  Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci USA. 2000;97(21):11439-44.
Background Reference 3:
Asao H, Okuyama C, Kumaki S, et al. the common γ-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167(1):1-5.
Background Reference 4:
Vosshenrich CA, Di Santo JP. Cytokines: IL-21 joins the γ(c)-dependent network Curr Biol. 2001;11(5):R175-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

2471

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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