IL-36 alpha Recombinant Protein

Background:

Human Interleukin-36 alpha (IL-36 alpha) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36 alpha is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36 alpha is the only IL-1 family member found to be expressed on T-cells. IL-36 alpha and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36 alpha inhibits PPAR gamma expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36 alpha, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36 alpha may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.