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IL-36 beta Recombinant Protein

CATALOG NUMBER: 90-283

Specifications
source-species:
E. coli
Species:
Mouse
source-species:
E. coli
Recombinant Protein Sequence:
Mouse IL-36beta (aa Ser31-Lys183) is untagged.
Fusion Tag:
Tag Free
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
Induces secretion of IL-6 in BMDCs at a concentration of 10 - 100ng/ml.
Purity:
>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
physical-state:
Lyophilized
Buffer:
Contains PBS + 0.5% Trehalose. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Storage Conditions:
Stable for at least 6 months after receipt when stored at -20°C.
Ncbi Official Symbol:
Il1f8
Additional Names:
Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8
Protein Accession Number:
Q9D6Z6
Protein Gi Number:
25008591
Ncbi Gene Id Number:
69677
Background:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-283

List Size:
10 ug

List Price:

$473.00

Datasheet
Shipping Info

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