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ILK (phospho Ser246) Antibody

CATALOG NUMBER: 79-847

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
ILK (phospho Ser246) antibody was raised against a peptide sequence around phosphorylation site of Serine 246 (I-F-S (p)-H-P) derived from Human ILK.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of ILK only when phosphorylated at serine 246.
Predicted Molecular Weight:
51 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
ILK
Additional Names:
ILK1, p59ILK, kinase ILK
Protein Accession Number:
NP_001014794.1
Protein Gi Number:
4758606
Ncbi Gene Id Number:
3611
Background:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Background Reference 1:
Hannigan G.E., Nature 379:91-96(1996).
Background Reference 2:
Janji B., Oncogene 19:3069-3077(2000).
Background Reference 3:
Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-847

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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