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Western blot analysis of ILPIP in human heart lysate with ILPIP antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) μg/mL, respectively.
Immunohistochemistry of ILPIP in human heart tissue with ILPIP antibody at 5 μg/mL.
Western blot analysis of ILPIP in human heart lysate with ILPIP antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) μg/mL, respectively.
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ILPIP Antibody

CATALOG NUMBER: 3201

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (73%)
Immunogen:
ILPIP antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human ILPIP.
The immunogen is located within the last 50 amino acids of ILPIP.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
ILPIP antibody can be used for the detection of ILPIP by Western blot at 0.5 to 2 μg/mL. Aa 34 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity:
Anti-ILPIP is specific for human ILPIP only.
Positive Control 1:
Cat. No. 1301 - Human Heart Tissue Lysate
Positive Control 2:
Cat. No. 10-501 - Human Heart Tissue Slide
Purification:
ILPIP Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
ILPIP Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
ILPIP antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
STRADB
Additional Names:
ILPIP Antibody: PAPK, ILPIP, ILPIPA, ALS2CR2, CALS-21, PRO1038, STE20-related kinase adapter protein beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, STRAD beta
Protein Accession Number:
NP_061041
Protein Gi Number:
13027388
Ncbi Gene Id Number:
55437
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ILPIP Antibody: ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1β converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
Background Reference 1:
Sanna MG, Correia JS, Luo Y, et al. (2002) ILPIP, a novel anti-apototic protein that enhances XIAP-mediated activation of JNK and protection of apoptosis. J. Biol. Chem. 277:30454-62.
Background Reference 2:
Sanna MG, Duckett CS, Richter BW, et al. (1998) Selective activation of JNK1 is necessary for the anti-apototic activity of hILP. Proc. Natl. Acad. Sci USA 95:6015-20.
Background Reference 3:
Nishigaki K, Thompson D, Yugawa T, et al. (2003) Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. J. Biol. Chem. 278:13520-30.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3201

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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