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Western blot analysis of IMPDH2 Antibody in NCI-H460,Hela,MCF7,A2058 cell line lysates(35ug/lane)
IMPDH2 Antibody IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Western blot analysis of IMPDH2 Antibody in NCI-H460,Hela,MCF7,A2058 cell line lysates(35ug/lane)

IMPDH2 Antibody

CATALOG NUMBER: 62-875

Clonality:
Polyclonal
Tested Applications:
Flow, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat, Hamster, Zebrafish
Immunogen:
This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human IMPDH2.
Conjugate:
Unconjugated
Tested Applications:
Flow, IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Predicted Molecular Weight:
56 kDa
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
IMPDH2
Additional Names:
Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255, HAMAP-Rule:MF_03156}, IMP dehydrogenase 2 {ECO:0000255, HAMAP-Rule:MF_03156}, IMPD 2 {ECO:0000255, HAMAP-Rule:MF_03156}, IMPDH 2 {ECO:0000255, HAMAP-Rule:MF_03156}, 111205 {ECO:0000255, HAMAP-Rule:MF_03156}, IMPDH-II, IMPDH2 {ECO:0000255, HAMAP-Rule:MF_03156}, IMPD2
Protein Accession Number:
P12268
Protein Gi Number:
124419
Ncbi Gene Id Number:
3615
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Background Reference 1:
Sombogaard,F., Pharmacogenet. Genomics 19 (8), 626-634 (2009)
Background Reference 2:
Mohamed,M.F., Genet. Test. 12 (4), 513-516 (2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

62-875

List Size:
400 ul

List Price:

$495.00

Datasheet
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