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Western blot analysis of INPP5D using rabbit polyclonal INPP5D Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the INPP5D gene (Lane 2).
Western blot analysis of INPP5D using rabbit polyclonal INPP5D Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the INPP5D gene (Lane 2).

INPP5D Antibody

CATALOG NUMBER: 61-547

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This INPP5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-796 amino acids from the Central region of human INPP5D.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
133 kDa
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
INPP5D
Additional Names:
Phosphatidylinositol 3,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP, SHIP1
Protein Accession Number:
Q92835
Protein Gi Number:
158564077
Ncbi Gene Id Number:
3635
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.
Background Reference 1:
Gilby,D.C., Leukemia 21 (11), 2390-2393 (2007)
Background Reference 2:
Gloire,G., Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)
Background Reference 3:
Vaillancourt,M., Cell. Signal. 18 (11), 2022-2032 (2006)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

61-547

List Size:
400 ul

List Price:

$495.00

Datasheet
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