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IHC testing of FFPE human spleen tissue with Integrin beta 3 antibody (clone ITGB3/1713). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.
IHC testing of FFPE human spleen tissue with Integrin beta 3 antibody (clone ITGB3/1713). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.

Integrin beta 3 Antibody [ITGB3/1713]

CATALOG NUMBER: 33-635

Clonality:
Monoclonal
Tested Applications:
Flow, IF, IHC-Fr, IHC-P
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Immunogen:
Human recombinant protein used as the immunogen for the Integrin beta 3 antibody.
Conjugate:
Unconjugated
Tested Applications:
Flow, IF, IHC-Fr, IHC-P
Application Note:
Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Immunofluorescence: 0.5-1 ug/ml
IHC (FFPE & Frozen): 1-2 ug/ml for 30 min at RT
Titration of the Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Purification:
Protein G affinity
Clonality:
Monoclonal
Isotype:
IgG1, kappa
Physical State:
Liquid
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Storage Conditions:
Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.
Ncbi Official Symbol:
ITGB3
Additional Names:
Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A
Ncbi Gene Id Number:
3690
User Note:
Optimal dilutions for each application to be determined by the researcher
Background:
Reacts with human Integrin beta 3, also called CD61. It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alphaIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

33-635

List Size:
100 ug

List Price:

$626.00

Datasheet
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