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Western blot analysis of lysed extracts from HL60 and HT29 cells using Integrin β3 (Ab-773).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Integrin β3 (Ab-773).
Western blot analysis of lysed extracts from HL60 and HT29 cells using Integrin β3 (Ab-773).

Integrin beta3 (Ab 773) Antibody

CATALOG NUMBER: 79-317

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
Integrin beta3 (Ab-773) antibody was raised against a peptide sequence around aa. 771~775 (P-L-Y-K-E) derived from Human Integrin β3.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
This antibody detects endogenous level of total Integrin β3 protein.
Predicted Molecular Weight:
110 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
ITGB3
Additional Names:
GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CREB2, CREBP1, Platelet membrane glycoprotein IIIa
Protein Accession Number:
NP_000203.2
Protein Gi Number:
47078292
Ncbi Gene Id Number:
3690
Background:
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Background Reference 1:
Chandhoke SK, et al. (2004) J Cell Sci; 117 (Pt 8): 1431-41. Datta A, et al. (2002) J Biol Chem; 277 (6): 3943-9. Law DA, et al. (1996) J Biol Chem; 271 (18): 10811-5.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-317

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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