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Western Blot at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).
IPO7 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western Blot at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 ug per lane.

IPO7 Antibody

CATALOG NUMBER: 61-926

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This IPO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 amino acids from the N-terminal region of human IPO7.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight:
120 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
IPO7
Additional Names:
Importin-7, Imp7, Ran-binding protein 7, RanBP7, IPO7, RANBP7
Protein Accession Number:
O95373
Ncbi Gene Id Number:
10527
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The importin-alpha/beta complex and the GTPase Ran mediatenuclear import of proteins with a classical nuclear localizationsignal. The protein encoded by this gene is a member of a class ofapproximately 20 potential Ran targets that share a sequence motifrelated to the Ran-binding site of importin-beta. Similar toimportin-beta, this protein prevents the activation of Ran's GTPaseby RanGAP1 and inhibits nucleotide exchange on RanGTP, and alsobinds directly to nuclear pore complexes where it competes forbinding sites with importin-beta and transportin. This protein hasa Ran-dependent transport cycle and it can cross the nuclearenvelope rapidly and in both directions. At least four importinbeta-like transport receptors, namely importin beta itself,transportin, RanBP5 and RanBP7, directly bind and import ribosomalproteins.
Background Reference 1:
Huang, S., et al. Biosci. Rep. 30(3):159-168(2010)
Background Reference 2:
Chachami, G., et al. Biochem. Biophys. Res. Commun. 390(2):235-240(2009)
Background Reference 3:
Adeyemo, A., et al. PLoS Genet.(7), E1000564 (2009) :
Background Reference 4:
Zaitseva, L., et al. Retrovirology 6, 11 (2009) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

61-926

List Size:
400 ul

List Price:

$495.00

Datasheet
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