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Western blot analysis of extracts from 293 cells treated with Heatshock using Phospho-IR (Tyr1355) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from 293 cells treated with Heatshock using Phospho-IR (Tyr1355) Antibody. The lane on the right is treated with the antigen-specific peptide.

IR (phospho Tyr1355) Antibody

CATALOG NUMBER: 79-989

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
IR (phospho Tyr1355) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1355 (R-S-Y (p)-E-E) derived from Human IR.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of IR only when phosphorylated at tyrosine 1355.
Predicted Molecular Weight:
95 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
INSR
Additional Names:
CD220 antigen, IR, insulin receptor, kinase InsR,
Protein Accession Number:
NP_000199.2
Protein Gi Number:
308153655
Ncbi Gene Id Number:
3643
Background:
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2.
Background Reference 1:
Tennagels N, et al. (2001) Biochem Biophys Res Commun 282, 387-93
Background Reference 2:
Tennagels N, Bergschneider E, Al-Hasani H, Klein HW (2000) FEBS Lett 479, 67-71
Background Reference 3:
Noelle V, Tennagels N, Klein HW (2000) Biochemistry 39, 7170-7

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-989

List Size:
0.1 mg

List Price:

$325.00

Out of stock

Datasheet
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