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IRAK Detection Set

CATALOG NUMBER: PSI-1802

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Species Reactivity:
Human
Specifications
Species Reactivity:
Human
Immunogen:
Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
Tested Applications:
IF, IHC, WB
Set Contents:
IRAK Antibody, Cat. No. 1007 (50 μg)

IRAK-2 (C2) Antibody, Cat. No. 2123 (50 μg)

IRAK-M Antibody, Cat. No. 2355 (50 μg)

IRAK-4 Antibody, Cat. No. 3125 (50 μg)

MyD88 Antibody, Cat. No. 2127 (50 μg)
Purification:
Antibodies are supplied as affinity chromatography purified IgG.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
PBS containing 0.02% sodium azide.
Concentration:
Antibody 1 mg/mL

Peptide 200 μg/mL
Storage Conditions:
Stable at 4°C for three months, store at -20°C for up to one year.
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Members of the IRAK (IL-1R-associated kinase)/Pelle family play a major role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK and IRAK-2 regulate the activity of a signaling cascade that mediates the activation of NF-κB and MAP kinase. IRAK-4 interacts with and phosphorylates IRAK, while IRAK-M is thought to inhibit the recruitment and activation of IRAK-4 and IRAK. The importance of the IRAK family in inflammation and immunity is illustrated by the fact that animals lacking IRAK-4 are impaired in their responses to viral and bacterial challenges and are completely resistant to LPS challenge.

For images please see PDF data sheet
Background Reference 1:
Cao Z, Henzel WJ, and Gao X. IRAK: a kinase associated with the interleukin-1 receptor.Science 1996; 271:1128-31.
Background Reference 2:
Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediator of IL-1 signaling. Science 1997; 278:1612-5.
Background Reference 3:
Li S, Strelow A, Fontana EJ, et al. IRAK-4: a novel member of the IRAK family with the properties of an IRAK kinase. Proc. Natl. Acad. Sci. USA 2002; 99:5567-72.
Background Reference 4:
Kobayashi K, Hernandez LD, Galan JE, et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 2002; 110:191-202.
Set Contents:
IRAK Antibody, Cat. No. 1007 (50 μg)

IRAK-2 (C2) Antibody, Cat. No. 2123 (50 μg)

IRAK-M Antibody, Cat. No. 2355 (50 μg)

IRAK-4 Antibody, Cat. No. 3125 (50 μg)

MyD88 Antibody, Cat. No. 2127 (50 μg)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

PSI-1802

List Size:
1 Set

List Price:

$849.00

Out of stock

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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