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Antibody used in WB on Human Liver at 0.2-1 ug/ml.
Antibody used in WB on Mouse Liver at: 1:50.
Antibody used in WB on Human Liver at 0.2-1 ug/ml.

IREB2 Antibody

CATALOG NUMBER: 25-623

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human IREB2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
IREB2 antibody can be used for detection of IREB2 by ELISA at 1:312500. IREB2 antibody can be used for detection of IREB2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Positive Control 1:
Cat. No. XBL-10409 - Fetal Liver Tissue Lysate
Predicted Molecular Weight:
105 kDa
Purification:
Antibody is purified by peptide affinity chromatography method.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Storage Conditions:
For short periods of storage (days) store at 4°C. For longer periods of storage, store IREB2 antibody at -20°C. As with any antibody avoid repeat freeze-thaw cycles.
Ncbi Official Symbol:
IREB2
Additional Names:
IREB2, ACO3, FLJ23381, IRP2, IRP2AD
Protein Accession Number:
NP_004127
Protein Gi Number:
41352693
Ncbi Gene Id Number:
3658
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
IREB2 binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. IREB2 binds to the IRE element in ferritin which results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Background Reference 1:
Zumbrennen, K.B., (2008) Biochim. Biophys. Acta 1783 (2), 246-252.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

25-623

List Size:
100 ul

List Price:

$519.00

Datasheet
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