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Irisin Recombinant Protein

CATALOG NUMBER: 90-316

Specifications
source-species:
CHO cells
Species:
Human, Mouse
source-species:
CHO cells
Recombinant Protein Sequence:
Irisin (human, aa 32-143 /mouse, aa 29-140) is DDDDK-tagged at the N-terminus. Irisin has 100% identity between mouse, rat, monkey and human.
Fusion Tag:
DDDDK Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
Activates brown adipocyte markers Ucp1 and Cidec in murine subcutaneous adipocytes at 10ng/ml [Lit. 1].
Purity:
>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
physical-state:
Lyophilized
Buffer:
Contains PBS. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Storage Conditions:
Stable for at least 6 months after receipt when stored at -20°C.
Ncbi Official Symbol:
FNDC5
Additional Names:
Fibronectin Type III Domain-containing Protein 5 (cleaved), Fibronectin Type III Repeat-containing Protein 2 (cleaved), FNDC5 (cleaved)
Protein Accession Number:
Q8NAU1
Protein Gi Number:
403314395
Ncbi Gene Id Number:
252995
Background:
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-316

List Size:
10 ug

List Price:

$540.00

Datasheet
Shipping Info

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