ITGAL Antibody

CATALOG NUMBER: 57-204

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This ITGAL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 722-751 amino acids from the Central region of human ITGAL.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
129 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ITGAL
Additional Names:
Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A
Protein Accession Number:
P20701
Protein Gi Number:
88911345
Ncbi Gene Id Number:
3683
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ITGAL encodes the integrin alpha L chain. Integrins areheterodimeric integral membrane proteins composed of an alpha chainand a beta chain. This I-domain containing alpha integrin combineswith the beta 2 chain (ITGB2) to form the integrin lymphocytefunction-associated antigen-1 (LFA-1), which is expressed on allleukocytes. LFA-1 plays a central role in leukocyte intercellularadhesion through interactions with its ligands, ICAMs 1-3(intercellular adhesion molecules 1 through 3), and also functionsin lymphocyte costimulatory signaling. Two transcript variantsencoding different isoforms have been found for this gene.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Kuwano, Y., et al. Blood 116(4):617-624(2010)
Background Reference 3:
Ghannam, S., et al. J. Immunol. 185(1):302-312(2010)
Background Reference 4:
Quist, S.R., et al. Acta Derm. Venereol. 90(4):429-430(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-204

List Size:
400 ul

List Price:

$495.00

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