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Jagged 1 Recombinant Protein

CATALOG NUMBER: 96-482

Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 34 - Ser 1046
Fusion Tag:
His Tag
Predicted Molecular Weight:
112.3 kDa
Purity:
>92% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
JAG1
Additional Names:
CD339, JAG1, Jagged1, hJ1, JAGL1
Protein Accession Number:
NP_000205
Ncbi Gene Id Number:
182
Background:
Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).
Background Reference 1:
Li L., et al., 1998, Immunity 8:43-55.
Background Reference 2:
Bash J., et al., 1999, EMBO J. 18:2803-2811.
Background Reference 3:
Zimrin A.B., et al., 1996, J. Biol. Chem. 271:32499-32502.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-482

List Size:
0.05 mg

List Price:

$515.00

Datasheet
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