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Western blot analysis in Hela cell line lysates (35ug/lane).
KCNA1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in Hela cell line lysates (35ug/lane).

KCNA1 Antibody

CATALOG NUMBER: 57-956

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This KCNA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the Central region of human KCNA1.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
56 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
KCNA1
Additional Names:
Potassium voltage-gated channel subfamily A member 1, Voltage-gated K(+) channel HuKI, Voltage-gated potassium channel HBK1, Voltage-gated potassium channel subunit Kv11, KCNA1
Protein Accession Number:
Q09470
Protein Gi Number:
223590092
Ncbi Gene Id Number:
3736
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a voltage-gated delayed potassiumchannel that is phylogenetically related to the Drosophila Shakerchannel. The encoded protein has six putative transmembranesegments (S1-S6), and the loop between S5 and S6 forms the pore andcontains the conserved selectivity filter motif (GYGD). Thefunctional channel is a homotetramer. The N-terminus of the channelis associated with beta subunits that can modify the inactivationproperties of the channel as well as affect expression levels. TheC-terminus of the channel is complexed to a PDZ domain protein thatis responsible for channel targeting. Mutations in this gene havebeen associated with myokymia with periodic ataxia (AEMK).
Background Reference 1:
Graves, T.D., et al. Neurology 75(4):367-372(2010)
Background Reference 2:
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 3:
van der Wijst, J., et al. J. Biol. Chem. 285(1):171-178(2010)
Background Reference 4:
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-956

List Size:
400 ul

List Price:

$495.00

Datasheet
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