KCNAB1 Antibody

Background:

Potassium channels represent the most complex class ofvoltage-gated ion channels from both functional and structuralstandpoints. Their diverse functions include regulatingneurotransmitter release, heart rate, insulin secretion, neuronalexcitability, epithelial electrolyte transport, smooth musclecontraction, and cell volume. Four sequence-related potassiumchannel genes - shaker, shaw, shab, and shal - have been identifiedin Drosophila, and each has been shown to have human homolog(s).This gene encodes a member of the potassium channel, voltage-gated,shaker-related subfamily. This member includes three distinctisoforms which are encoded by three alternatively splicedtranscript variants of this gene. These three isoforms are betasubunits, which form heteromultimeric complex with alpha subunitsand modulate the activity of the pore-forming alpha subunits.