KCNJ1 Antibody

CATALOG NUMBER: 60-256

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This KCNJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-374 amino acids from the C-terminal region of human KCNJ1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
45 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
KCNJ1
Additional Names:
ATP-sensitive inward rectifier potassium channel 1, ATP-regulated potassium channel ROM-K, Inward rectifier K(+) channel Kir11, Potassium channel, inwardly rectifying subfamily J member 1, KCNJ1, ROMK1
Protein Accession Number:
P48048
Protein Gi Number:
1352479
Ncbi Gene Id Number:
3758
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Potassium channels are present in most mammalian cells,where they participate in a wide range of physiologic responses.The protein encoded by this gene is an integral membrane proteinand inward-rectifier type potassium channel. It is activated byinternal ATP and probably plays an important role in potassiumhomeostasis. The encoded protein has a greater tendency to allowpotassium to flow into a cell rather than out of a cell. Mutationsin this gene have been associated with antenatal Bartter syndrome,which is characterized by salt wasting, hypokalemic alkalosis,hypercalciuria, and low blood pressure. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 3:
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Background Reference 4:
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-256

List Size:
400 ul

List Price:

$495.00

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