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Western blot analysis of KCNK1 in 3T3 cell lysate with KCNK1 antibody at 1 μg/ml.
Immunohistochemistry of KCNK1 in mouse brain tissue with KCNK1 antibody at 5 μg/ml.
Immunofluorescence of KCNK1 in mouse brain tissue with KCNK1 antibody at 20 μg/ml.
Western blot analysis of KCNK1 in 3T3 cell lysate with KCNK1 antibody at 1 μg/ml.
Trial Size

KCNK1 Antibody

CATALOG NUMBER: 8017

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%), Guinea pig: (100%)
Immunogen:
KCNK1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KCNK1.
The immunogen is located within amino acids 220 - 270 of KCNK1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
KCNK1 antibody can be used for detection of KCNK1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity:
KCNK1 antibody is human, mouse and rat reactive. KCNK1 antibody is predicted to not cross-react with other KCNK proteins.
Positive Control 1:
Cat. No. 1212 - 3T3 Cell Lysate
Predicted Molecular Weight:
Predicted: 37 kDa
Observed: 35 kDa
Purification:
KCNK1 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
KCNK1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
KCNK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
KCNK1
Additional Names:
Potassium channel subfamily K member 1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1
Protein Accession Number:
NP_002236
Protein Gi Number:
4504847
Ncbi Gene Id Number:
3775
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The potassium channel, subfamily K, member 1 (KCNK1), is member of the superfamily of potassium channel proteins containing two pore-forming P domains (1,2). KCNK1 is a ubiquitous human weakly inward rectifying K+ channel that is widely expressed in human tissues, and particularly abundant in brain and heart (1). Both KCNK1 and the related protein KCNK2 contribute significantly to the passive conductance of hippocampal astrocytes (3).
Background Reference 1:
Lesage F, Guillemare E, Fink M, et al. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 1996; 15:1004-11.
Background Reference 2:
Goldstein SA, Bockenhauer D, O'Kelly I, et al. Potassium leak channels and the KCNK family of two-P domain subunits. Nat. Rev. Neurosci. 2001; 2:175-84.
Background Reference 3:
Zhou M, Xu G, Xie M, et al. TWIK-1 and TREK-2 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slides. J. Neurosci. 2009; 29:8551-64.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8017

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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