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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).

KCNN1 Antibody

CATALOG NUMBER: 59-038

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This KCNN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human KCNN1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
60 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
KCNN1
Additional Names:
Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa21, KCNN1, SK
Protein Accession Number:
Q92952
Protein Gi Number:
124056468
Ncbi Gene Id Number:
3780
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Action potentials in vertebrate neurons are followed by anafterhyperpolarization (AHP) that may persist for several secondsand may have profound consequences for the firing pattern of theneuron. Each component of the AHP is kinetically distinct and ismediated by different calcium-activated potassium channels. Theprotein encoded by this gene is activated before membranehyperpolarization and is thought to regulate neuronal excitabilityby contributing to the slow component of synaptic AHP. The encodedprotein is an integral membrane protein that forms avoltage-independent calcium-activated channel with three othercalmodulin-binding subunits. This gene is a member of the KCNNfamily of potassium channel genes.
Background Reference 1:
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Background Reference 2:
Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)
Background Reference 3:
Arnold, S.J., et al. Neuroreport 14(2):191-195(2003)
Background Reference 4:
Boettger, M.K., et al. Brain 125 (PT 2), 252-263 (2002) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-038

List Size:
400 ul

List Price:

$495.00

Datasheet
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