KDELR1 Antibody

Background:

Retention of resident soluble proteins in the lumen of theendoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, whichis a seven-transmembrane protein. Unlike yeast, several humanhomologs of the ERD2 gene, constituting the KDEL receptor genefamily, have been described. The protein encoded by this gene wasthe first member of the family to be identified, and it encodes aprotein structurally and functionally similar to the yeast ERD2gene product.