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Western blot analysis of KHDC1 in rat liver tissue lysate with KHDC1 antibody at (A) 0.5 and (B) 1 μg/mL.
Immunohistochemistry of KHDC1 in human liver tissue with KHDC1 antibody at 5 μg/mL.
Western blot analysis of KHDC1 in rat liver tissue lysate with KHDC1 antibody at (A) 0.5 and (B) 1 μg/mL.
Trial Size

KHDC1 Antibody

CATALOG NUMBER: 7423

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
KHDC1 antibody was raised against a 15 amino acid peptide near the amino terminus of human KHDC1.
The immunogen is located within amino acids 30 - 80 of KHDC1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
KHDC1 antibody can be used for detection of KHDC1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity:
KHDC1 antibody is human, mouse and rat reactive. At least three isoforms of KHDC1 are known to exist; this antibody will only detect the longest isoform.
Positive Control 1:
Cat. No. 1464 - Rat Liver Tissue Lysate
Positive Control 2:
Cat. No. 10-201 - Human Liver Tissue Slide
Predicted Molecular Weight:
Predicted: 18 kDa
Observed: 26 kDa
Purification:
KHDC1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
KHDC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
KHDC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
KHDC1
Additional Names:
KHDC1 Antibody: NDG1, C6orf148, bA257K9.4, KH homology domain-containing protein 1
Protein Accession Number:
NP_085045
Protein Gi Number:
117956389
Ncbi Gene Id Number:
80759
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
KHDC1 Antibody: KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability (1). KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs (2,3). KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities (3,4).
Background Reference 1:
Valverde R, Edwards L, and Regan L. Structure and function of KH domains. FEBS J. 2008; 275:2712–26.
Background Reference 2:
Pierre A, Gautier M, Callebaut I, et al. Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. Genomics 2007; 90:583-94.
Background Reference 4:
Cai C, Liu J, Wang C, et al. KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosis. DNA Cell Biol. 2012; 31:1447-57.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7423

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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