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Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

KINDLIN3 Antibody

CATALOG NUMBER: 4797

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
KINDLIN3 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human KINDLIN3.
The immunogen is located within the last 50 amino acids of KINDLIN3.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
KINDLIN3 antibody can be used for detection of KINDLIN3 by Western blot at 1 and 2 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1466 - Rat Spleen Tissue Lysate
Predicted Molecular Weight:
Predicted: 73 kDa
Observed: 73 kDa
Purification:
KINDLIN3 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
KINDLIN3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
KINDLIN3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FERMT3
Additional Names:
KINDLIN3 Antibody: URP2, KIND3, MIG-2, MIG2B, URP2SF, UNC112C, URP2, Fermitin family homolog 3, Kindlin-3
Protein Accession Number:
NP_848537
Protein Gi Number:
41281905
Ncbi Gene Id Number:
83706
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
KINDLIN3 Antibody: The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
Background Reference 1:
Ussar S, Wang HV, Linder S, et al. The Kindlins: subcellular localization and expression during murine development. Exp. Cell Res.2006; 312:3142-51.
Background Reference 2:
Weinstein EJ, Bourner M, Head R, et al. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. Biochim. Biophys. Acta2003; 1637:207-16.
Background Reference 3:
Boyd RS, Adam PJ, Patel S, et al. Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. Leukemia2003; 17:1605-12.
Background Reference 4:
Mory A, Feigelson SW, Yarali N, et al. Kindlin-3: a new gene involved in the pathogenesis of LAD-III. Blood2008; 112:2591.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4797

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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