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Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).
Western blot analysis in Hela cell line lysates (35ug/lane).
Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).

KLHL12 Antibody

CATALOG NUMBER: 59-118

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Zebrafish, Rat, Xenopus
Immunogen:
This KLHL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human KLHL12.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
63 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
KLHL12
Additional Names:
Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog, hDKIR, KLHL12, C3IP1
Protein Accession Number:
Q53G59
Protein Gi Number:
97054498
Ncbi Gene Id Number:
59349
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
Background Reference 1:
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Background Reference 2:
Rondou, P., et al. J. Biol. Chem. 283(17):11083-11096(2008)
Background Reference 3:
Lim, J., et al. Cell 125(4):801-814(2006)
Background Reference 4:
Angers, S., et al. Nat. Cell Biol. 8(4):348-357(2006)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-118

List Size:
400 ul

List Price:

$495.00

Datasheet
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