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Western blot analysis of KPNA7 in human spleen with KPNA7 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of KPNA7 in human placenta tissue with KPNA7 antibody at 5 μg/mL.
Western blot analysis of KPNA7 in human spleen with KPNA7 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Trial Size

KPNA7 Antibody

CATALOG NUMBER: 5993

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
KPNA7 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA7.
The immunogen is located within amino acids 40 - 90 of KPNA7.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
KPNA7 antibody can be used for detection of KPNA7 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity:
KPNA7 antibody is human specific. KPNA7 antibody is predicted to not cross-react with other Importin alpha family members.
Purification:
KPNA7 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
KPNA7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
KPNA7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
KPNA7
Additional Names:
KPNA7 Antibody: Importin subunit alpha-8, Karyopherin subunit alpha-7
Protein Accession Number:
NP_001139187
Protein Gi Number:
224589129
Ncbi Gene Id Number:
402569
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
KPNA7 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.
Background Reference 1:
Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene. Expr. 1997; 7:61-72.
Background Reference 2:
Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem. 2003; 278: 51937-49.
Background Reference 3:
Tejomurtula J, Lee KB, Tripurani SK, et al. Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle. Biol. Reprod. 2009; 81:333-42.
Background Reference 4:
Kelley JB, Talley AM, Spencer A, et al. Karyopherin a7 (KPNA7), a divergent member of the importin a family of nuclear import receptors. BMC Cell Biol. 2010; 11:63.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5993

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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