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Human Kremen-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Dkk-1, His Tag at 2 ug/mL (100 uL/well) can bind Human Kremen-1, Fc Tag with a linear range of 0.02-0.313 ug/mL (QC tested).
Human Kremen-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Kremen-1 Recombinant Protein

CATALOG NUMBER: 11-155

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Arg 21 - Thr 392
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 67.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
67.4 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Names:
KREMEN, KRM1Dickkopf receptor/Kringle domain-containing transmembrane protein 1/Kringle-containing protein marking the eye and the nose
Background:
Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6). Kremen1 is considered as one component of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates. Additionally, KREMEN1 (KRM1) has also been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD).
Background Reference 1:
Mishra SK. et al., PLoS One. 2012;7(12): e52190.
Background Reference 2:
Bingyu M. et al., Nature,. 2002 Jun 6;417(6889):664-7.
Background Reference 3:
Yingzi C. et al., PNAS, 2020 117 (31) 18711-18718

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-155

List Size:
0.1 mg

List Price:

$658.00

Datasheet
Shipping Info

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