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ntracellular FACS testing of K562 cells with PE conjugated Ku70 + Ku80 antibody(red) and isotype control (green).
ntracellular FACS testing of K562 cells with PE conjugated Ku70 + Ku80 antibody(red) and isotype control (green).

Ku70 + Ku80 Antibody [LKAP1-1]

CATALOG NUMBER: 34-024

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Immunogen:
A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.
Conjugate:
Unconjugated
Tested Applications:
Flow
Application Note:
Flow cytometry: 0.5-1ug/10e6 cells
Titering of the Ku70 + Ku80 antibody may be required for optimal performance.
Purification:
Protein G purified
Clonality:
Monoclonal
Isotype:
IgG1, kappa
Physical State:
Liquid
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Storage Conditions:
Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.
Ncbi Official Symbol:
XRCC6
Additional Names:
X-ray repair cross-complementing protein 6, 364-, 4299-, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Ku70, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6, XRCC6, G22P1
Ncbi Gene Id Number:
2547
User Note:
Optimal dilutions for each application to be determined by the researcher
Background:
Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

34-024

List Size:
100 ug

List Price:

$626.00

Datasheet
Shipping Info

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