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LATS1/2 (phospho Thr1079/1041) Antibody

CATALOG NUMBER: 79-850

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
LATS1/2 (phospho Thr1079/1041) antibody was raised against a peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T (p)-F-R) derived from Human LATS1/2 .
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of LATS1/2 only when phosphorylated at threonine 1079/1041.
Predicted Molecular Weight:
126 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20˚,C for up to one year.
Ncbi Official Symbol:
LATS1, LATS2
Additional Names:
WARTS, Large tumor suppressor 1, EC 2.7.11.1
Protein Accession Number:
NP_004681.1
Protein Gi Number:
4758666
Ncbi Gene Id Number:
9113;26524
Background:
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding.
Background Reference 1:
Tao W., Nat. Genet. 21:177-181(1999).
Background Reference 2:
Nishiyama Y., FEBS Lett. 459:159-165(1999).
Background Reference 3:
The MGC Project Team, Genome Res. 14:2121-2127(2004).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-850

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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