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Western blot analysis of LGI2 in 293 cell lysate with LGI2 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of LGI2 in 293 cell lysate with LGI2 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

LGI2 Antibody

CATALOG NUMBER: 4491

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
LGI2 antibody was raised against a 11 amino acid synthetic peptide from near the amino terminus of human LGI2.
The immunogen is located within the first 50 amino acids of LGI2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
LGI2 antibody can be used for the detection of LGI2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins. Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest.
Positive Control 1:
Cat. No. 1210 - HEK293 Cell Lysate
Purification:
LGI2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
LGI2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
LGI2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
Lgi2
Additional Names:
LGI2 Antibody: mKIAA1916, Kiaa1916, Leucine-rich repeat LGI family member 2, Leucine-rich glioma-inactivated protein 2
Protein Accession Number:
Q8N0V4
Protein Gi Number:
32469737
Ncbi Gene Id Number:
246316
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
LGI2 Antibody: The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.
Background Reference 1:
Gu W, Gibert Y, Wirth T, et al. Using gene-history and expression analysis to assess the involvement of LGI genes in human disorders. Mol. Biol. Evol.2005; 22:2209-16.
Background Reference 2:
Chernova OB, Somerville RP and Cowell JK. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene1998; 17:2873-81.
Background Reference 3:
Berkovic SF, Izzillo P, McMahon JM, et al. LGI1 mutations in temporal lobe epilepsies. Neurology2004; 62:1115-9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4491

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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