LGMN Antibody

Background:

This gene encodes a cysteine protease that has a strictspecificity for hydrolysis of asparaginyl bonds. This enzyme may beinvolved in the processing of bacterial peptides and endogenousproteins for MHC class II presentation in the lysosomal/endosomalsystems. Enzyme activation is triggered by acidic pH and appears tobe autocatalytic. Protein expression occurs after monocytesdifferentiate into dendritic cells. A fully mature, active enzymeis produced following lipopolysaccharide expression in maturedendritic cells. Overexpression of this gene may be associated withthe majority of solid tumor types. This gene has a pseudogene onchromosome 13. Several alternatively spliced transcript variantshave been described, but the biological validity of only two hasbeen determined. These two variants encode the same isoform.