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The purity of rh LIFR Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh LIFR Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

LIFR Recombinant Protein

CATALOG NUMBER: 96-522

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 45 - Ser 833
Fusion Tag:
C-Fc Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
115.5 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human LIF, Tag Free at 0.2ug/mL (100 uL/well) can bind Human LIF R, Fc Tag with a linear range of 7.8-31.25 ng/mL.
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
LIFR
Additional Names:
LIFR, CD118, FLJ98106, FLJ99923, SJS2, STWS, SWS
Protein Accession Number:
NP_001121143
Ncbi Gene Id Number:
3977
Background:
Leukemia inhibitory factor receptor is also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.
Background Reference 1:
Timmermann, Andreas, et al. 2002, Eur. J. Biochem. (Germany) 269 (11): 2716–26.
Background Reference 2:
Gearing, D.P. et al.,1991, EMBO J. 10 (10): 2839-2848.
Background Reference 3:
Gearing, D.P. et al.,1992, New Biol. 4 (1): 61-65.
Background Reference 4:
Mosley, B. et al.,1996, J. Biol. Chem. 271 (51): 32635-32643.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-522

List Size:
0.2 mg

List Price:

$577.00

Datasheet
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