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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).

LMNA Antibody

CATALOG NUMBER: 59-797

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
74 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
LMNA
Additional Names:
Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Protein Accession Number:
P02545
Protein Gi Number:
125962
Ncbi Gene Id Number:
4000
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The nuclear lamina consists of a two-dimensional matrix ofproteins located next to the inner nuclear membrane. The laminfamily of proteins make up the matrix and are highly conserved inevolution. During mitosis, the lamina matrix is reversiblydisassembled as the lamin proteins are phosphorylated. Laminproteins are thought to be involved in nuclear stability, chromatinstructure and gene expression. Vertebrate lamins consist of twotypes, A and B. Through alternate splicing, this gene encodes threetype A lamin isoforms. Mutations in this gene lead to severaldiseases: Emery-Dreifuss muscular dystrophy, familial partiallipodystrophy, limb girdle muscular dystrophy, dilatedcardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilfordprogeria syndrome.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Wegner, L., et al. J. Clin. Endocrinol. Metab. 95(8):3884-3892(2010)
Background Reference 3:
Drac, H., et al. Neurol. Neurochir. Pol. 44(3):291-296(2010)
Background Reference 4:
Liu, Q., et al. PLoS ONE(5), E10874 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-797

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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