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Western blot analysis of LRRC26 in human prostate tissue lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of LRRC26 in human prostate tissue with LRRC26 antibody at 2.5 μg/mL.
Immunohistochemistry of LRRC26 in human prostate tissue with LRRC26 antibody at 2.5 μg/ml.
Western blot analysis of LRRC26 in Jurkat cell lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of LRRC26 in human prostate tissue with LRRC26 Antibody at 20 μg/mL.
Western blot analysis of LRRC26 in human prostate tissue lysate with LRRC26 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Trial Size

LRRC26 Antibody

CATALOG NUMBER: 7539

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
LRRC26 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LRRC26.
The immunogen is located within the last 50 amino acids of LRRC26.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
LRRC26 antibody can be used for detection of LRRC26 by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
LRRC26 antibody is human specific.
Positive Control 1:
Cat. No. 1312 - Human Prostate Tissue Lysate
Positive Control 2:
Cat. No. 1205 - Jurkat Cell Lysate
Predicted Molecular Weight:
Predicted: 37 kDa
Observed: 48 kDa
Purification:
LRRC26 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
LRRC26 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
LRRC26 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
LRRC26
Additional Names:
LRRC26 Antibody: CAPC, bA350O14.10, CAPC, Leucine-rich repeat-containing protein 26, BK channel auxiliary gamma subunit LRRC26
Protein Accession Number:
NP_001013675
Protein Gi Number:
61966761
Ncbi Gene Id Number:
389816
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The LRRC26 protein was initially identified as a cytokeratin-associated protein whose expression was elevated in multiple cancer cell lines and cancer specimens as well in normal prostate and salivary gland tissues (1). LRRC26 was later found to negatively regulate the NF-kappaB activation and suppresses tumor growth and metastasis (2). LRRC26 can also act to selectively alter the efficacy of large conductance calcium-activated K (BK) channels (3).
Background Reference 1:
Egland KA, Liu XF, Squires S, et al. High expression of a cytokeratin-associated protein in many cancers. Proc. Natl. Acad. Sci. USA 2006; 103:5929-34.
Background Reference 2:
Liu XF, Xiang L, Zhang Y, et al. CAPC negatively regulates NF-?B activation and suppresses tumor growth and metastasis. Oncogene 2012; 31:1673-82.
Background Reference 3:
Almassy J and Begenisich T. The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 2012; 81:21-30.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7539

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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