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LTbetaR Antibody [4H8 WH2] (preservative free)

CATALOG NUMBER: 36-101

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Immunogen:
Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Application Note:
Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
Specificity:
Recognizes mouse LTbetaR.
Purification:
>95% (SDS-PAGE)
Clonality:
Monoclonal
Isotype:
IgG2a
physical-state:
Liquid
Buffer:
Liquid. In PBS containing 10% glycerol. Preservative free formulation.
Concentration:
1 mg/ml
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C.
Ncbi Official Symbol:
Ltbr
Additional Names:
Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
Protein Accession Number:
1729988
Protein Gi Number:
P50284
Ncbi Gene Id Number:
17000
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

36-101

List Size:
100 ug

List Price:

$525.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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