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LTbetaR non-lytic Recombinant Protein

CATALOG NUMBER: 90-536

Specifications
source-species:
CHO cells
Species:
Human
source-species:
CHO cells
Recombinant Protein Sequence:
The extracellular domain of human LTbetaR (aa 31-225) is fused to the N-terminus of the Fc region of a mutant human IgG1.
Fusion Tag:
Fc Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
Shows the biological function of the LTbetaR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
physical-state:
Lyophilized
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Ncbi Official Symbol:
LTBR
Additional Names:
Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3
Protein Accession Number:
NP_002333
Protein Gi Number:
4505039
Ncbi Gene Id Number:
4055
Background:
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-536

List Size:
100 ug

List Price:

$515.00

Datasheet
Shipping Info

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