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Western blot analysis of LXR-B in human lung tissue lysate with LXR-B antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of LXR-B in human lung tissue lysate with LXR-B antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

LXR-B Antibody

CATALOG NUMBER: 5579

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
LXR-B antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human LXR-B.
The immunogen is located within the first 50 amino acids of LXR-B.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
LXR-B antibody can be used for detection of LXR-B by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1302 - Human Lung Tissue Lysate
Purification:
LXR-B Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
LXR-B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
LXR-B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
NR1H2
Additional Names:
LXR-B Antibody: NER, UNR, LXRB, LXR-b, NER-I, RIP15, NER, Oxysterols receptor LXR-beta, Liver X receptor beta
Protein Accession Number:
P55055
Protein Gi Number:
1709254
Ncbi Gene Id Number:
7376
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
LXR-B Antibody: LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer's disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
Background Reference 1:
Willy PJ, Umesono K, Ong ES, et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev.1995; 9:1033-45.
Background Reference 2:
Edwards PA, Kennedy MA, and Mak PA. LXRs; Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vasc. Pharmacol.2002; 38:249-56.
Background Reference 3:
Bensinger SJ and Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature2008; 454:470-7.
Background Reference 4:
Adighibe O, Arepalli S, Duckworth J, et al. Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease. Nerobiol. Aging2006; 27:1431-4.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5579

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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