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MAP3K8 (phospho Ser400) Antibody

CATALOG NUMBER: 79-852

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
MAP3K8 (phospho Ser400) antibody was raised against a peptide sequence around phosphorylation site of Serine 400 (C-Q-S (p)-L-D) derived from HumanMAP3K8.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of MAP3K8 only when phosphorylated at serine 400.
Predicted Molecular Weight:
52 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
MAP3K8
Additional Names:
C-COT;, M3K8, MAP3K8, TPL2
Protein Accession Number:
NP_001231063.1
Protein Gi Number:
22035598
Ncbi Gene Id Number:
1326
Background:
This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1).
Background Reference 1:
Miyoshi J., Mol. Cell. Biol. 11:4088-4096(1991).
Background Reference 2:
Aoki M., J. Biol. Chem. 268:22723-22732(1993).
Background Reference 3:
Chan A.M.,Oncogene 8:1329-1333(1993).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-852

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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