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Western blot analysis of MARVELD1 in mouse heart tissue lysate with MARVELD1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of MARVELD1 in mouse heart tissue lysate with MARVELD1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

MARVELD1 Antibody

CATALOG NUMBER: 5499

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
MARVELD1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human MARVELD1.
The immunogen is located within the first 50 amino acids of MARVELD1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
MARVELD1 antibody can be used for detection of MARVELD1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1401 - Mouse Heart Tissue Lysate
Purification:
MARVELD1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
MARVELD1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
MARVELD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MARVELD1
Additional Names:
MARVELD1 Antibody: MRVLDC1, MARVEL domain-containing protein 1
Protein Accession Number:
EAW49903
Protein Gi Number:
119570288
Ncbi Gene Id Number:
83742
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
MARVELD1 Antibody: MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.
Background Reference 1:
Wang S, Li Y, Han F, et al. On of MARVELD1, a novel nuclear protein that is down-regulated in multiple cancers and silenced by DNA methylation. Cancer Lett.2009; 282:77-86.
Background Reference 2:
Alves PM, Levy N, Stevenson BJ, et al. Identification of tumor-associated antigens by large scale analysis of genes expressed in human colorectal cancer. Cancer Immun.2008; 8:11.
Background Reference 3:
Hatada I, Fukasawa M, and Kimura M. Genome-wide profiling of promoter methylation in human. Oncogene2006; 25:3059-64.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5499

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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