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Western blot analysis in Hela cell line lysates (35ug/lane).
Western blot analysis in Hela cell line lysates (35ug/lane).

MASP1 Antibody

CATALOG NUMBER: 59-666

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This MASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-507 amino acids from the Central region of human MASP1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
79 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MASP1
Additional Names:
Mannan-binding lectin serine protease 1, 3421-, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5, Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, MASP1, CRARF, CRARF1, PRSS5
Protein Accession Number:
P48740
Protein Gi Number:
218512135
Ncbi Gene Id Number:
5648
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a serine protease that functions as acomponent of the lectin pathway of complement activation. Thecomplement pathway plays an essential role in the innate andadaptive immune response. The encoded protein is synthesized as azymogen and is activated when it complexes with the pathogenrecognition molecules of lectin pathway, the mannose-binding lectinand the ficolins. This protein is not directly involved incomplement activation but may play a role as an amplifier ofcomplement activation by cleaving complement C2 or by activatinganother complement serine protease, MASP-2. The encoded protein isalso able to cleave fibrinogen and factor XIII and may may beinvolved in coagulation. A splice variant of this gene which lacksthe serine protease domain functions as an inhibitor of thecomplement pathway. Alternate splicing results in multipletranscript variants.
Background Reference 1:
Kocsis, A., et al. J. Immunol. 185(7):4169-4178(2010)
Background Reference 2:
Degn, S.E., et al. J. Immunol. Methods 361 (1-2), 37-50 (2010) :
Background Reference 3:
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Background Reference 4:
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-666

List Size:
400 ul

List Price:

$495.00

Datasheet
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