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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
MBTPS2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).

MBTPS2 Antibody

CATALOG NUMBER: 56-769

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
57 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MBTPS2
Additional Names:
Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P
Protein Accession Number:
O43462
Ncbi Gene Id Number:
51360
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a intramembrane zinc metalloprotease,which is essential in development. This protease functions in thesignal protein activation involved in sterol control oftranscription and the ER stress response. Mutations in this genehave been associated with ichthyosis follicularis with atrichia andphotophobia (IFAP syndrome); IFAP syndrome has been quantitativelylinked to a reduction in cholesterol homeostasis and ER stressresponse.
Background Reference 1:
Ming, A., et al. Pediatr Dermatol 26(4):427-431(2009)
Background Reference 2:
Oeffner, F., et al. Am. J. Hum. Genet. 84(4):459-467(2009)
Background Reference 3:
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Background Reference 4:
Shen, J., et al. J. Biol. Chem. 279(41):43046-43051(2004)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-769

List Size:
400 ul

List Price:

$495.00

Datasheet
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