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Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).
Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).

MCM3 Antibody

CATALOG NUMBER: 57-424

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This MCM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human MCM3.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
91 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MCM3
Additional Names:
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3
Protein Accession Number:
P25205
Protein Gi Number:
19857543
Ncbi Gene Id Number:
4172
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areinvolved in the initiation of eukaryotic genome replication. Thehexameric protein complex formed by MCM proteins is a key componentof the pre-replication complex (pre_RC) and may be involved in theformation of replication forks and in the recruitment of other DNAreplication related proteins. This protein is a subunit of theprotein complex that consists of MCM2-7. It has been shown tointeract directly with MCM5/CDC46. This protein also interactswith, and thus is acetlyated by MCM3AP, a chromatin-associatedacetyltransferase. The acetylation of this protein inhibits theinitiation of DNA replication and cell cycle progression. [providedby RefSeq].
Background Reference 1:
Lau, K.M., et al. Oncogene 29(40):5475-5489(2010)
Background Reference 2:
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 3:
Lee, Y.S., et al. Exp. Mol. Pathol. 88(1):138-142(2010)
Background Reference 4:
Song, Y.J., et al. Acta Virol. 54(2):125-130(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-424

List Size:
400 ul

List Price:

$495.00

Datasheet
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