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Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).

MDM4 Antibody

CATALOG NUMBER: 57-314

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This MDM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human MDM4.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
55 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MDM4
Additional Names:
Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX
Protein Accession Number:
O15151
Ncbi Gene Id Number:
4194
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The human MDM4 gene, which plays a role in apoptosis,encodes a 490-amino acid protein containing a RING finger domainand a putative nuclear localization signal. The MDM4 putativenuclear localization signal, which all Mdm proteins contain, islocated in the C-terminal region of the protein. The mRNA isexpressed at a high level in thymus and at lower levels in allother tissues tested. MDM4 protein produced by in vitro translationinteracts with p53 via a binding domain located in the N-terminalregion of the MDM4 protein. MDM4 shows significant structuralsimilarity to p53-binding protein MDM2. Two transcript variants,one protein-coding and the other likely not to be protein-coding,have been found for this gene.
Background Reference 1:
Xu, N., et al. Biochem. Biophys. Res. Commun. 401(3):417-421(2010)
Background Reference 2:
Sarkari, F., et al. J. Mol. Biol. 402(5):825-837(2010)
Background Reference 3:
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Background Reference 4:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-314

List Size:
400 ul

List Price:

$495.00

Datasheet
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