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Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).

MED17 Antibody

CATALOG NUMBER: 58-351

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This MED17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-361 amino acids from the Central region of human MED17.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
73 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
MED17
Additional Names:
Mediator of RNA polymerase II transcription subunit 17, Activator-recruited cofactor 77 kDa component, ARC77, Cofactor required for Sp1 transcriptional activation subunit 6, CRSP complex subunit 6, Mediator complex subunit 17, Thyroid hormone receptor-associated protein complex 80 kDa component, Trap80, Transcriptional coactivator CRSP77, Vitamin D3 receptor-interacting protein complex 80 kDa component, DRIP80, MED17, ARC77, CRSP6, DRIP77, DRIP80, TRAP80
Protein Accession Number:
Q9NVC6
Protein Gi Number:
296437366
Ncbi Gene Id Number:
9440
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The activation of gene transcription is a multistepprocess that is triggered by factors that recognize transcriptionalenhancer sites in DNA. These factors work with co-activators todirect transcriptional initiation by the RNA polymerase IIapparatus. The protein encoded by this gene is a subunit of theCRSP (cofactor required for SP1 activation) complex, which, alongwith TFIID, is required for efficient activation by SP1. Thisprotein is also a component of other multisubunit complexes e.g.thyroid hormone receptor-(TR-) associated proteins which interactwith TR and facilitate TR function on DNA templates in conjunctionwith initiation factors and cofactors.
Background Reference 1:
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Background Reference 2:
Jang, M.K., et al. Mol. Cell 19(4):523-534(2005)
Background Reference 3:
Tomomori-Sato, C., et al. J. Biol. Chem. 279(7):5846-5851(2004)
Background Reference 4:
Sato, S., et al. J. Biol. Chem. 278(17):15123-15127(2003)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-351

List Size:
400 ul

List Price:

$495.00

Datasheet
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